In this month’s JCI, Poulos et al. reveal that the age of bone marrow endothelial cells (BMECs) strongly influences hematopoietic stem cell characteristics. Whereas aged endothelium imparted an aging phenotype to young hematopoietic stem cells, young endothelium rescued many of the deficits observed in aged cells. In the cover image, upregulation of ROS (magenta) represents one age-related defect observed in older BMECs (visualized in red and green with blue nuclei).
Image credit: Michael Gutkin.
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