A Hurler patient-derived cartilaginous pellet-based system recapitulates disease-associated skeletal alterations and highlights dysregulation of molecular pathways that may contribute to the altered phenotype.

A vaccine that iduces only SARS-CoV-2-S-specific T cells provides marked protection against viral challenge, supporting effectiveness of current COVID-19 vaccines against SARS-CoV-2 variants.

Sectm1a regulates macrophage efferocytosis in ischemic/reperfused hearts.

The adaptive response of the right ventricle following left ventricle infarction at postnatal day 1 enables marked cardiac regeneration and full functional recovery.

ADAMTSL2 variant-espressing models replicate the phenotypic heterogeneity of geleophysic dysplasia in mice, with severity linked to impaired ADAMTSL2 secretion.

A2 methylation of GNAS is regulated by STX16 and NESP55 imprinting control regions, and GNAS A2 methylation status enables pseudohypoparathyroidism type 1B categorization.

SON haploinsufficient mice serve as an animal model of Zhu-Tokita-Takenouchi-Kim syndrome and identify indispensable SON functions in multi-organ development and hematopoiesis.

HMGB1 increases platelet surface P2Y12 and promotes platelet ADP release, thereby enhancing ADP-mediated platelet activation in healthy subjects and individuals with sickle cell disease.

In the aged immune system, naive CD4⁺ T cells are selected for increased expression of PREX1 that endows them with enhanced IL7 responsiveness.

TNFR2 is a driver of the key characteristics of effector/memory Treg cells in a wide range of non-lymphoid tissues in health and disease.

Iron regulatory proteins 1 and 2 modulate the immune response and tissue damage during uropathogenic Escherichia coli-mediated orchitis.

Mucosal-associated invariant T cells have an intrinsic regulatory function that suppresses alloreactive T cell responses that protect against GVHD in vitro and in vivo.

The negative mTOR regulator DDIT4L has a developmental role in human neonatal myeloid cell by limiting cytokine production and reconfiguring mitochondrial dynamics.

IL-1 promotes antibody production after germinal center T and B cell interaction, while IL-1 receptor 2 from regulatory cells inhibits IL-1 and reduces antibody generation.

The purine nucleoside phosphorylase inhibitor 8-aminoguanine reduces pain and prevents damage in a rat model of hemorrhagic cystitis.

Excessive gut epithelial cell fucosylation increases the risk of colon cancer in the elderly.

Norepinephrine exposure promotes a prometastatic phenotype in fallopian tube epithelial cells that potentiates micrometastasis of high grade serous carcinoma precursor lesions to the ovary.

Baseline and activated IL-33 expression can be regulated in the respiratory epithelium and these pathways are dysregulated in chronic airway disease.

Receptor tyrosine kinase AXL drives of early differentiation of allograft-infiltrating monocytes to inflammatory macrophages, and AXL inhibition prolongs allograft survival.

SARS-CoV-2 mRNA vaccination reduces innate, T cell, and B cell immune responses in patients with systemic lupus erythematosus, highlighting a need for population-specific vaccination studies.

Endothelial DNA/RNA-binding protein TDP-43 is essential for formation of a stable and mature vasculature, and loss of TDP-43 results in vascular defects and inflammation.

CDK1 inhibition prevents vascular calcification through induction of E-twenty-six specific sequence variant 2.